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Marie-Claude Kilhoffer Selected Research

Glioblastoma (Glioblastoma Multiforme)

8/2019Lebbeckoside C, a new triterpenoid saponin from the stem barks of Albizia lebbeck inhibits the growth of human glioblastoma cells.
6/2018WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling.
6/2017Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells. Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling.
1/2016The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
1/2015Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells.
1/2015Glioblastoma and calcium signaling--analysis of calcium toolbox expression.
1/2014Comparative expression study of the endo-G protein coupled receptor (GPCR) repertoire in human glioblastoma cancer stem-like cells, U87-MG cells and non malignant cells of neural origin unveils new potential therapeutic targets.
6/2009Calcium fingerprints induced by calmodulin interactors in eukaryotic cells.

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Marie-Claude Kilhoffer Research Topics

Disease

10Neoplasms (Cancer)
08/2019 - 01/2014
8Glioblastoma (Glioblastoma Multiforme)
08/2019 - 06/2009
2Glioma (Gliomas)
08/2019 - 01/2015
1Carcinogenesis
01/2018
1Hypertension (High Blood Pressure)
01/2016
1Brain Neoplasms (Brain Tumor)
01/2015

Drug/Important Bio-Agent (IBA)

3Bisacodyl (Bicol)FDA Link
06/2018 - 01/2015
2CalciumIBA
01/2018 - 01/2015
2Cytotoxins (Cytolysins)IBA
06/2017 - 01/2015
1SaponinsIBA
08/2019
1TriterpenesIBA
08/2019
1lebbeckoside CIBA
08/2019
1Phosphotransferases (Kinase)IBA
06/2018
1Adrenergic Receptors (Adrenergic Receptor)IBA
01/2016
1Antihypertensive Agents (Antihypertensives)IBA
01/2016
1Prazosin (Minipress)FDA LinkGeneric
01/2016
1LaxativesIBA
01/2015
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2014
1W 7 (W7)IBA
06/2009
1Coloring Agents (Dyes)IBA
06/2009
1AequorinIBA
06/2009
1indo-1IBA
06/2009
1W 12IBA
06/2009
1bifonazoleIBA
06/2009
1N- (4- aminobutyl)- 5- chloro- 2- naphthalenesulfonamide (W13)IBA
06/2009
1calmidazoliumIBA
06/2009

Therapy/Procedure

7Therapeutics
01/2018 - 01/2014
2Drug Therapy (Chemotherapy)
01/2018 - 06/2016
2Radiotherapy
06/2016 - 01/2014
1Aftercare (After-Treatment)
01/2014